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However, one study presented conflicting results in mice, reporting a current-dependent increase in the firing rates of L5p following DOI application (2050 nA) (De Gregorio et al., 2021)

Pharmacol Ther 244:108373

[19] Augmentation [edit] If therapy with antidepressants (such as selective serotonin reuptake inhibitors [SSRIs]) does not fully treat and discontinue [38] the symptoms of major depressive disorder (MDD) (also known as refractory depression or treatment resistant depression [TRD]) [39] then a second augmentation agent is sometimes added to the therapy

303 Additionally, inhibition of mitochondrial respiration failed to rescue the ES/Cu toxicity, 303 and intracellular copper can be released from the ES/Cu complex and become bioavailable outside the mitochondria, suggesting a great likelihood of mitochondrial-independent cuproptosis